Kuliah Umum oleh Sachiko Kana di Pasca Sarjana Bioteknologi UGM

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Kuliah Terbuka Sachiko Kana 01.JPG

Sebuah kuliah umum yang diberikan oleh Sachiko Hirosue di Pasca Sarjana Bioteknologi UGM. Acara ini diselenggarakan oleh Pasca Sarjana Bioteknologi UGM melalui kerjasama dengan Hackteria dan lifepatch.

Deskripsi Acara

Pada kuliah umum ini, Sachiko Hirosue akan memberikan kuliah mengenai nano partikel poly untuk mengeluarkan cairan kelenjar getah bening (Propylene Sulfide) sebagai platform vaksin. Kuliah ini akan berlangsung dalam bahasa inggris yang dimoderatori oleh Nur Akbar Arofatullah. Acara terbuka untuk umum. Bagi yang tertarik mohon datang sesuai dengan tempat dan waktu yang ditetapkan.

Detail Acara

Acara ini akan berlangsung pada:

Materi Kuliah

Kuliah ini akan diberikan oleh Sachiko Hirosue, seorang ilmuan biologi dari Jepang yang kini berbasis di Swiss.

Judul Kuliah

Lymphatic draining poly (propylene sulfide) nanoparticles as vaccine platforms.

SACHIKO HIROSUE, Sc.D. Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

Abstrak

Clinically successful vaccinations in infectious disease settings mainly rely on the induction of antibodies to neutralize the infectious agent. Vaccine formulations have still yet to fully take advantage of the cellular branch of the adaptive immune response. Antigens and adjuvants carried on nano-sized particles have shown promise in the induction of such an immune response. We have established the lymphatic draining, complement activating pluronic stabilized poly (propylene sulfide) nanoparticles as possible vaccine agents (1). The size and chemistry alters the association of the particulates with different organs, and also in varied antigen presenting cell compartments after intradermal immunization. Nanoparticle associated antigen is successfully presented by antigen presenting cells (2), and elicits both humoral and cellular immune responses (3). In intrapulmonary immunizations, we have shown that the antigen-specific (Ag85B, and model antigen ovalbumin) cellular responses are capable of minimizing the impact of a challenge by the infectious agent (mycobacterium tuberculosis, and influenza) in the mouse model (4).

Referensi

  • 1. S. T. Reddy et al., Exploiting lymphatic transport and complement activation in nanoparticle vaccines. Nat Biotechnol 25, 1159 (Oct, 2007).
  • 2. S. Hirosue, I. C. Kourtis, A. J. van der Vlies, J. A. Hubbell, M. A. Swartz, Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation. Vaccine 28, 7897 (Nov 23, 2010).
  • 3. A. Stano et al., PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration. Vaccine 29, 804 (Jan 17, 2011).
  • 4. M. Ballester et al., Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis. Vaccine29, 6959 (Sep 16, 2011).

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